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Sunifiram DM-235 AMPA Receptors Positive Allosteric Modulator C14H18N2O2

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Wuhan Yuancheng Technology Development Co., Ltd.
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Sunifiram DM-235 AMPA Receptors Positive Allosteric Modulator C14H18N2O2

Brand Name : Ycphar
Model Number : 314728-85-3
Place of Origin : China
Payment Terms : Western Union, Money Gram, Bitcoin
Delivery Time : 3-7 days
Packaging Details : Stealth Package
Certification : ISO9001
CAS : 314728-85-3
Product Name : Sunifiram
Color : White
M.F. : C14H18N2O2
M.W. : 246.30492
Standard : USP,CP
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Sunifiram DM-235 AMPA Receptors Positive Allosteric Modulator C14H18N2O2
Quick Detail of Sunifiram
1. Alias: Sunifiram (DM-235)
2. CAS No.: 314728-85-3
3. EINECS: 219-034-4
4. Molecular Formula: C14H18N2O2
5. Assay: 99%
6. Molecular Weight: 246.30492
7. Appearance: Off-white to white crystalline powder.
General Infomation Of Sunifiram
Description:
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).
Sunifiram (DM-235) is a synthetic derivative of Piracetam, although due to breaking the pyrrolidone backbone it is no longer in the Racetam class of drugs (yet by being derived from them, it is still commonly associated with this class).
Sunifiram has mechanisms similar to Nefiracetam in the hippocampus, and similar to that drug sunifiram shows anti-amnesiac properties and is potentially a cognitive enhancer. Its anti-amnesiac activity is several orders of magnitude greater than piracetam on a per weight basis, and preliminary evidence suggest it has a similarly low toxicity profile.
This compound is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate). This enhancement of AMPA function seems to also rely on enhancing signalling via the Glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).
This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation.
Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.
Sunifiram Benifits:
Sunifiram increases energy levels, allowing users to feel more motivated and eliminate
Sunifiram increase Levels of concentration increase, and users feel less distracted by external stimuli Sunifiram also enhances long- term potentiation, which is the forming of new connections regarding memory storage.Sunifiram has some anxiolyic benefits.
Feeling more relaxed is beneficial when trying to focus.
Sunifiram DOSING:
Like what was mentioned above, the typical dose for an adult human would be approximately 5mg of sunifiram. The strength of the effects are greater when it is taken sublingually (i.e. under the tongue) as opposed to just swallowing it. Don't worry too much if you go over the standard dose, though! Sunifiram has extremely low toxicity and a huge range between therapeutic and dangerous amounts.
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